ABSTRACT
No abstract available.
ABSTRACT
BACKGROUND: Narrowband UVB (NBUVB) is currently used to treat early mycosis fungoides (MF). There are a number of reports on the efficacy and safety of NBUVB in Caucasians, but little data is available for Asians. OBJECTIVE: This study was designed to evaluate the effectiveness and safety of NBUVB for early stage MF in Korean patients. METHODS: We enrolled 14 patients (12 men, 2 women; age range, 10~64 years) with clinically and histologically proven MF. Three patients were stage IA, and the others were stage IB. The patients received NBUVB phototherapy three times a week. The starting dose was 70% of the minimal erythema dose and was increased in 20 percent increments if the previous treatment did not cause erythema. Clinical response, total number of treatments, total cumulative dose, duration of remission and side effects were investigated. RESULTS: Eleven of 14 patients (78.6%) achieved complete remission within a mean of 15.36+/-5.71 weeks (range, 5~27 weeks), 31.0+/-7.4 treatments (range, 16~39 treatments) and a mean cumulative UVB dose of 31.31+/-12.16 J/cm2 (range, 11.4~46.8 J/cm2). Three of the 14 patients (21.4%) achieved a partial remission. After discontinuation of treatment, 6 of 11 patients (54.5%) with complete remission relapsed after a mean of 8.5+/-4.09 months. No serious adverse effects were observed except for hyperpigmentation (7/14, 50%). CONCLUSION: Our data suggest that NBUVB therapy is safe and effective for the treatment of early stage MF in Korean patients.
Subject(s)
Humans , Male , Asian People , Erythema , Hyperpigmentation , Mycosis Fungoides , PhototherapyABSTRACT
Pseudoxanthoma elasticum (PXE) is a heritable disorder of elastic tissue and it has many systemic manifestations. PXE is a systemic disorder that most markedly affects the elastic tissues in the skin, retina and blood vessels. Defects in the ABCC6 gene lead to calcification of elastic tissue. We herein report on two cases of pseudoxanthoma elasticum that presented with focal involvement on the skin of the neck without marked wrinkling.
Subject(s)
Blood Vessels , Elastic Tissue , Neck , Pseudoxanthoma Elasticum , Retina , SkinABSTRACT
Superficial basal cell carcinoma (sBCC), a rare sub-type of basal cell carcinoma, can frequently occur in younger patients. This cancer type preferentially develops on the trunk. However, other subtypes of BCC can occur in the head and neck, probably secondary to sunlight exposure. Especially, sBCC on the scalp has been rarely-reported, accounting for 0.7~0.8% of all sBCC cases. We report a case of 71-year-old female with a large sBCC of the scalp, an unusual site of sBCC.
Subject(s)
Aged , Female , Humans , Accounting , Carcinoma, Basal Cell , Head , Neck , Scalp , SunlightABSTRACT
Lymphomatoid papulosis (LyP) is a chronic lymphoproliferative disorder characterized by the appearance of crops of papules, nodules, and sometimes large plaques at different stages of development. Pseudocarcinomatous hyperplasia (PCH) presents with extreme proliferation of the epidermis with downgrowth into the dermis, which histologically mimics the features of squamous cell carcinoma. However, squamous cells usually are well differentiated, and atypicalities, such as individual cell keratinization, nuclear hyperplasia, and hyperchromasia, are minimal or absent. PCH has rarely been reported in LyP. Here, we showed that PCH associated with LyP may closely resemble squamous cell carcinoma, thereby giving rise to wrong diagnosis and treatment.
Subject(s)
Carcinoma, Squamous Cell , Dermis , Epidermis , Hyperplasia , Keratins , Lymphomatoid Papulosis , Lymphoproliferative DisordersABSTRACT
Hidradenitis Suppurativa (HS) is a chronic relapsing disease that involves the apocrine gland-bearing skin. It results in sinus tract formation, fibrosis and scarring. Many different treatments for HS have been reported, including topical and systemic antibiotics, intralesional steroids, systemic retinoids, hormonal therapies and immnunosuppressive agents, but they all have limited beneficial effects. Surgical treatments, including wide exteriorization with secondary intention, a skin graft and a flap can be effective treatments for recalcitrant HS. We present here the case of a 26-year-old man with recurred inguinal and axillary HS, and this was treated with secondary healing and a split thickness skin graft after exteriorization. Based on our experience, it is suggested that secondary healing and a split thickness skin graft after exteriorization are effective for recalcitrant HS with multiple interconnected tracts and abscesses.
Subject(s)
Adult , Humans , Abscess , Anti-Bacterial Agents , Cicatrix , Fibrosis , Hidradenitis , Hidradenitis Suppurativa , Intention , Retinoids , Skin , Steroids , TransplantsABSTRACT
Botryomycosis is a chronic, granulomatous and suppurative infection. The skin is the most frequently affected organ. The most common species is Staphylococcus aureus, followed by Pseudomonas aeruginosa. Clinically, the skin lesions most commonly affect the hands and feet and they can appear as nodules, ulcers, sinuses, fistulae and verrucous plaques. Histopathologic examination reveals grains with surrounding eosinophilic material and inflammatory cells. We report here on a case of botryomycosis at the excoriation site in a 90-year-old female patient with chronic eczema.
Subject(s)
Aged, 80 and over , Female , Humans , Edible Grain , Eczema , Eosinophils , Fistula , Foot , Hand , Pseudomonas aeruginosa , Skin , Staphylococcus aureus , UlcerABSTRACT
BACKGROUND: Ultraviolet (UV) radiation has been used for decades to treat a variety of skin diseases. UVA1 was used initially as an effective treatment for acute exacerbated atopic dermatitis. Since then, UVA1 has been attempted for recalcitrant skin diseases. OBJECTIVE: This study examined the efficacy of UVA1 phototherapy in three recalcitrant skin diseases. METHODS: This retrospective study reviewed the efficacy and follow-up of 26 patients with atopic dermatitis (AD), mycosis fungoides (MF) and localized scleroderma (LS). SUPUVASUN 3000 (Mutzhas Co., Munich, Germany) and SELLAMED 3000 (Sellas Medizinische Gerate GmbH, Gevelsberg, Germany) were the UVA1 equipment used. Irradiation was performed in accordance with the disease. Low-dose (20 J/cm2), medium-dose (65 J/cm2) and high-dose regimens (100 J/cm2) of UVA1 therapy were employed. The frequency of the therapy ranged from 3 to 5 times weekly. The therapeutic effectiveness was assessed according to the clinical examination before and after the last treatment. RESULTS: In patients with AD, complete and partial remission was achieved in four (80%) and one (20%) patient, respectively. In patients with MF, complete and partial remission was observed in thirteen (86.7%) and two (13.3%) patients, respectively. In patients with LS, complete and partial remission was observed in three (50%) and three (50%) patients, respectively. CONCLUSION: UVA1 phototherapy is an effective treatment modality for acute exacerbated AD, MF and LS.
Subject(s)
Humans , Dermatitis, Atopic , Follow-Up Studies , Mycosis Fungoides , Phototherapy , Retrospective Studies , Scleroderma, Localized , Skin , Skin DiseasesABSTRACT
Edema blisters is an acute bullous disease that occurs following acute lower leg edema in patients with heart, renal and liver disease. Most of the affected patients are elderly, immobile and have been hospitalized for a long time. These clinical situations are commonly observed, but this can be misdiagnosed as other bullous diseases, especially friction blisters and bullous pemphigoid. We herein report a case of acute edema blisters in a 74-year-old female who presented with a tense bullae based on an edematous lower leg.
Subject(s)
Aged , Female , Humans , Blister , Edema , Friction , Heart , Leg , Liver Diseases , Pemphigoid, Bullous , Transcutaneous Electric Nerve StimulationABSTRACT
Cowden syndrome (CS) is a rare genodermatosis that is characterized by multiple hamartomatous tumors of an ectodermal, mesodermal and endodermal origin. CS is associated with an increased risk of malignancy and especially breast cancer, thyroid cancer, uterine cancer and renal cell carcinoma. The characteristic features of the disease are mucocutaneous findings, including multiple facial trichilemmomas, oral mucosal papillomatosis and acral keratoses. Multiple sclerotic fibroma is also known to be a clue to diagnose CS. We herein emphasize that multiple sclerotic fibromas of the skin are an important marker of CS, which may also be helpful for making an early diagnosis.
Subject(s)
Breast Neoplasms , Carcinoma, Renal Cell , Early Diagnosis , Ectoderm , Endoderm , Fibroma , Hamartoma Syndrome, Multiple , Keratosis , Mesoderm , Papilloma , Skin , Thyroid Neoplasms , Uterine NeoplasmsABSTRACT
Hyaluronic acid fillers have been proposed as an alternative to other temporary skin fillers for treating facial skin lines and providing soft tissue augmentation. There is no antigenic specificity for species or tissue; thus, these agents have a low potential for allergic or immunogenic reaction. However, there are a few reports about allergic hypersensitivity reactions to hyaluronic acid. We report here on the case of a woman who developed a delayed hypersensitivity reaction to the non-animal stabilized hyaluronic acid filler, Restylane(R).
Subject(s)
Female , Humans , Epitopes , Hyaluronic Acid , Hypersensitivity , Hypersensitivity, Delayed , SkinABSTRACT
The incidence of cutaneous metastases of primary tumor has been reported to be rare, as compared with metastasis of other internal organ. Carcinoma of the breast is most common cause of cutaneous metastasis in women. We report here on a case of telangiectactic metastatic breast carcinoma in a 65-year-old female who had violaceous plaques and vesicles over the right side of the neck. Histopathological examinations of the cutaneous lesion revealed aggregations of tumor cells within the dilated blood vessels in the dermis.